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Description

However, compensatory enhancement of the NRF2 pathway enables cancer cells to resist high ROS environments and develop chemoresistance [396]

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Iron ions in the form of Fe 2+ or Fe 3+ reside in cells i n vivo, and iron homeostasis maintains the relatively stable content of these ions through transferrin receptor 1 (TFR1)-regulated iron transport, ferroportin 1 (FPN1)-mediated iron output storage, and ferritin-regulated iron storage (Fig

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