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Inhibitory potential of myricetin for IAPP aggregation T2DM is characterized as a metabolic disorder with defects in both insulin secretion and insulin action, and is also characterized by the presence of fibrillar amyloid deposits in the pancreatic islet of Langerhans, suggesting that T2DM is classified to protein-misfolding disease

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NHS prescribing of Rybelsus and metformin is governed by NICE guidance and local commissioning policies, with strict eligibility criteria that focus primarily on diabetes management rather than weight loss alone

therefore, assessing the methodological quality or risk of bias of the included studies was not mandatory