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In contrast, the open lactone form of OTA, found in biological samples from various species, can exert similar or higher toxicity than OTA (Dekant et al

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At 40 mg/mL, it equals 12.5 units

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The biomarker changes (lower blood pressure, better lipid profile) are favourable and create a reasonable prior expectation, but the dedicated cardiovascular outcomes trial (TRIUMPH-Outcomes) is not expected to report until late 2027 or early 2028

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