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10.1152/physiolgenomics.00193.2006 37

10,193,194 iNAMPT localizes to the cytoplasm, nucleus and mitochondria, and NAMPT has also been found to be upregulated in several solid human tumors, including the colon cancer, 7 glioma 8,9 and breast, 195 prostate, 196 thyroid, 197 and gastric 198 carcinomas

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Concurrent with reductions in expression of GPx-1 (and other selenoproteins), these mice show enhanced susceptibility to precancerous changes in a model of prostate cancer and to preneoplastic alterations indicative of colon cancer susceptibility in another model system (98, 182)