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In vivo demonstration Conceptual extension of emerging in vitro findings was performed by testing the potential effect of oral LASSS administration on prevention of muscle disuse-induced nitration-dysfunction of ECM-bound HGF (at Y198 and Y250 in K1 and K2 domains, respectively) 64

Sample size Allowing for potential participant attrition, the total sample size for the study is 60 (30 per arm)

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doi: 10.1136/gut.50.5.585

This also suggests that future clinical trials using SAM to treat depression may need to consider chronotypes as a confounder that may have been the origin of failed clinical trials

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