The dasatinib-plus- quercetin combination cleared senescent cells in a first-in-human trial, and a small feasibility trial is testing it in Alzheimers, though the brain evidence is early
Mitchell AL, Hickey B, Hickey JL, Pearce SHS
I cant disclose what's in it, but its an improvement and an advance on that, and weve done a number of animal studies
In addition, 2.0 M Compound K (CK), a metabolite of ginsenoside produced by intestinal flora, increases the expression of Gcg and GLP-1 secretion and promotes L-cell differentiation under high-glucose conditions (50 mM) in NCI-H716 cells
A sustained decrease in ATP levels leads to a relative increase in the intracellular AMP content, and blocking ATP production triggers cellular senescence, which is demonstrated by an increase in the expression levels of two proteins, p16INK4A and p21CIP1/WAF1 [93]
These findings suggest that AML improved antioxidant defence mechanisms and reduced MDA levels, thereby preventing the tissue damage caused by ROS
