[11] [12] Renal impairment : Most DPP-4 inhibitors require dose adjustment in renal impairment
more frequent dosing rarely has a strong scientific justification and mainly increases exposure and risk
human clinical trial data is essentially non-existent
Clinical trials have not reported serious side effects at doses up to 1,000 mg per day
In addition, the GLP-1 can inhibit postprandial gastric emptying and reduce gastric acid secretion, inhibit gastric and duodenal peristalsis by inhibiting vagus nerve, and increase the pressure of pylorus, thus reducing appetite, causing a reduction in body weight and participating in the so-called ileal braking effect (35)
( PMID: 25545186 ) Ko JW, Park KD, Lee Y, Lee JH, Hong DK (2020) Eosinophilic panniculitis following the subcutaneous injection of exenatide extended-release