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2022 NEJM SURMOUNT-1 2,539 72
Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIH
Both peroxyl radicals and alkoxyl radicals are further cyclized and dependent on the type of polyunsaturated fatty acid, degraded into reactive aldehydes such as 4-hydroxynonenal (4-HNE) or malondialdehyde (MDA) (Fig
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The generation of oxidative DNA lesions, such as 8-oxoguanine (8-oxoG), is linked to the development of various cancers, including melanoma, while the accumulation of these lesions can compromise genomic stability, leading to mutations and the eventual transformation of normal cells into malignant ones 53
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