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Although the sample size was small with only 48 total participants randomized across the two treatment conditions, the randomized, double-blinded, experimental design provides some compelling preliminary evidence that semaglutide might reduce alcohol craving and the amount of alcohol consumed on drinking days in people with alcohol use disorder not actively seeking treatment

Zero human evidence not weak evidence, zero

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Tian et al., 2019

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10 Melasma is sometimes divided into epidermal, dermal and mixed types on the basis of the level of melanin deposition in the epidermis (epidermal melanosis) and/or the dermis (dermal melanosis)