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That substitution is important because it gives the fragment its fat-targeting properties without activating the broader growth hormone receptor pathways that cause problems like insulin resistance and abnormal tissue growth

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Nicoletti F, Bruno V, Ngomba RT, Gradini R, Battaglia G

doi: 10.1126/science.1247606

doi: 10.3969/j.issn.1005-5304.2016.07.021 118