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10.1172/JCI111682
for forearm fracture the crude HR was 1.12 [0.851.47] and the fully adjusted HR 1.06 [0.791.41], and for any fracture the crude HR was 1.01 [0.901.13], and the fully adjusted HR was 0.97 [0.86-1.09] when comparing GLP-1 RAs with DPP-4is
Considering an estimated average blood volume of approximately 7%8% of body weight in mice ( in vitro IC50 of 613 M for hepatocytes, taking into account the rapid distribution and metabolism occurring in vivo
While encouraging, this studys retrospective design, lack of placebo control, small sample size, and subjective outcome reporting limit its interpretability