Recently approved by the US Food and Drug Administration (FDA) as the first oral GLP-1RA for treating T2DM, Sema has demonstrated cardiovascular benefits in clinical trials involving patients with T2DM 16
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Lilly's triple agonist retatrutide posts its strongest weight loss numbers yet, setting up a 2027 FDA filing Eli Lilly, this week, reported positive topline results from TRIUMPH-2 and TRIUMPH-3, two pivotal Phase 3 trials of retatrutide, a once-weekly injectable that activates receptors for GIP, GLP-1, and glucagon simultaneously a triple mechanism that no approved obesity therapy currently matches
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Its once-weekly injection makes it a more convenient choice for those with busy lifestyles
Among patients who switched from AOM tirzepatide to a different GLP-1, the majority transitioned to AOM semaglutide, aligning with its status as the CVS Caremark preferred therapy