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As reviewed, there is good evidence of renoprotection across many of the GLP1RA trials (Table 3) and SGLT2i trials (Table 1), including recent evidence on the use of canagliflozin in the CREDENCE trial focused on patients with T2DM and diabetic nephropathy, and of dulaglutide in the AWARD7 trial

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In summary, GLP-1 and its analogues appear to exert multiple important actions in brain, liver, muscle and fat in addition to its main action of stimulating insulin secretion

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