Dysregulation of the mitochondrial ACE2/MrgE/NO axis may have a significant effect on the neurodegenerative processes of dopaminergic neurons, where mitochondrial dysfunction and oxidative stress may have a substantial impact [76]
Conley BA, Staudt L, Takebe N, Wheeler DA, Wang L , Cardenas MF, Korchina V, Zenklusen JC, McShane LM, Tricoli JV, Williams PM, Lubensky I, O'Sullivan-Coyne G, Kohn E, Little RF, White J, Malik S, Harris LN, Mann B, Weil C, Tarnuzzer R, Karlovich C, Rodgers B, Shankar L, Jacobs PM, Nolan T, Berryman SM, Gastier-Foster J, Bowen J, Leraas K, Shen H, Laird PW, Esteller M, Miller V, Johnson A, Edmondson EF, Giordano TJ, Kim B, Ivy SP
Loss of mpc1 reprograms retinal metabolism to impair visual function
doi: 10.1007/s00018-020-03700-x
W wielkich randomizowanych badaniach klinicznych z lat 20152019 stwierdzono istotne zmniejszenie ryzyka wystpienia tzw
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