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-MSH binding to MC1R results in the activation of adenylyl cyclase, increasing the intracellular levels of cAMP and subsequently upregulating TYR, tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2) expression

Missing a dose or administering it at a different time each day can disrupt the protocol

W., Ting, Y

Wilding et al., NEJM, 2021

Resources on muscle loss during GLP-1 therapy provide additional context for those concerned about this issue

Soliqua 100/33 (active ingredients: insulin glargine and lixisenatide) subcutaneous injection Initial FDA Approval: 2016 Side Effect Update Date: May 28, 2025 Medication Description: Treats type 2 diabetes Updated Side Effects/Safety Information: A new warning section on Severe Gastrointestinal Adverse Reactions. An additional new warning about the risk of serious kidney injury caused by dehydration due to gastrointestinal adverse effects like diarrhea and vomiting