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Skin substitute expenditures, on average for PY 2024, represent roughly 1 percent of total Parts A and B expenditures for ACOs, and with truncation applied, the average skin substitute expenditures equate to less than 0.5 percent of total Parts A and B expenditures for ACOs

First, GLP-1 treatment options were extremely limited

Response: We acknowledge these comments but believe that the language in Section 1115A(d)(2) of the Act gives the Innovation Center the authority to implement and test ASM

Any adjustments to the 5-Amino-1MQ dosage should be made with careful consideration for animal ethics guidelines and regulatory approvals

Biomolecules (2021) 13

So, their long-term safety remains unknown