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Abstract Heart failure (HF) remains one of the cardiovascular diseases (CVDs) associated with a high unmet medical need due to high morbidity and mortality rates and lack of efficacious interventions

The MHRA encourages reporting of any suspected adverse drug reactions through the Yellow Card scheme (yellowcard.mhra.gov.uk)

A., Horbinski, C

In July 2023, the European Medicines Agency 206 and the UK Medicines and Healthcare products Regulatory Agency (MHRA) 230 started a review of these medications safety following reports of worsening mood and suicidal behavior observed in GLP-1RA users

(2014) 130:15798810.1161/CIRCULATIONAHA.114.010389 67

doi: 10.1038/s41467-022-28683-0 111 FriasJPNauckMAVanJKutnerMECuiXBensonCet al