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Although epacadostat achieved a favorable response rate of 55% in combination with pembrolizumab for the use in patients with solid tumors from a phase I/II trial, which led to a phase III study to evaluate the efficacy of epacadostat in 706 unresectable melanoma patients, the results from the larger trial revealed that epacadostat plus pembrolizumab did not provide an improved overall survival or progression-free survival

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The lower limits of detection of the assays were 44.2 pmol l 1 , 2.04 nmol l 1 , 0.5 mol l 1 and 0.1 mg g 1 creatinine 1 for serum cobalamin, serum folate, plasma homocysteine and urine MMA, respectively

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