The effects of GLP-1s increase postprandial insulin secretion from pancreatic -cells, suppress glucagon secretion from -cells, slow gastric emptying, and reduce appetite (Gross)
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Microdosing GLP-1 lacks clinical trial evidence and regulatory approval, making its safety profile unknown
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Thus, based on the results of CV outcomes trials with incretin-based agents, clinical priority of GLP-1RAs may be accentuated when choosing antidiabetic agents, at least for T2D patients at higher risk of CV events