Notably, siRNA-mediated inhibition of both AMPK and SIRT6 reversed the GLP-1RA-induced suppression of SREBP-2 expression in PA-treated cells (Fig
Mono- and combination therapies differentially enhance beta cell identity and attenuate beta cell stress and immunogenicity To elucidate the molecular mechanisms underlying beta cell protection by mono- and combination therapies, we performed spatial transcriptomic profiling of pancreatic sections from 12- and 17-week-old untreated mice, as well as from mice 5 weeks after receiving aCD3 monotherapy, GLP1-E2 monotherapy or aCD3+GLP1-E2 combination therapy
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A small-molecule (modulator) triple agonist of GCGR, GIPR, and GLP-1R