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For people on lower doses like the starting 2.5 mg dose , this trough can drop below the threshold needed for meaningful appetite suppression

and (6) low-fat and low-carbohydrate and high-protein

Limitations and Considerations BMI cutoff used is in between the typical cutoffs for overweight and obese Limited generalizability given that the majority of patients included were Caucasian, with only 12.5% African American male predominant population studied, with only 27.7% females It remains to be demonstrated if treatment with semaglutide has a cardioprotective and preventative benefit in patients who do not have pre-existing cardiovascular disease PowellWiley TM, Poirier P, Burke LE, et al

So the optimal dose is not necessarily the maximum dose

No reconstitution

Patients should not discontinue Ozempic without consulting their prescriber, as abrupt cessation may affect glycaemic control