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Science (2006) 313(5790):113740.10.1126/science.1128294 138 OtaTGayetCGinsbergHN

It contains the highest concentration of leucine, the amino acid that triggers muscle protein synthesis

In a meta-analysis of three trials, with a total of 1,119 participants, those with PAM variants were less responsive to the drugs and less successful in lowering their HbA1c, a measure of average blood sugar levels

Clin J Am Soc Nephrol CJASN

Wang B, Zhong J, Lin H, et al

mutations are mutations that involve conservative substitutions or other mutations in a small number of residues of the antibody or binding protein, e.g., in 5, 4, 3, 2 or 1 of the residues of the antibody or binding protein, preferably e.g., in 5, 4, 3, 2 or 1 of the residues making up one or more of the CDRs of the antibody or binding protein