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They can act as signaling molecules such as hormones or neurotransmitters in many organisms, and they are also present in other biological compounds like antibiotics, which interact with biological systems in complex ways

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IDO in the tumor microenvironment: inflammation, counter-regulation, and tolerance

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The SNP was shown to have minimal conformational or stereochemical effects on MDA5 itself but is thought to impair the CTD domain within MDA5, weakening the interaction of the protein with dsRNA

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