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S-Acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism

For example, the substitution of L-alanine with D-alanine at the 2nd position might improve resistance to molecular breakdown

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Imoto S, Kono M, Suzuki T, Shibuya Y, Sawamura T, Mizokoshi Y, et al

In this study, the authors demonstrated that siRNA-mediated knockdown of HNF4 initiates a microRNA-inflammatory feedback loop that continuously suppresses HNF4 expression and sustains a stable phenotype of tumorigenesis 56