administration, resulting in flaccid paralysis (Renew, 2026) Succinylcholine's effect during Phase I block is purely postsynaptic and results from a relatively constant reduction in twitch amplitude caused by the prolonged occupancy of postsynaptic nAChRs by succinylcholine, which interferes with the normal acetylcholine-mediated neurotransmission when a motoneuron is stimulated (Figure 2)(Jonsson et al, 2006) Clinically: Equal reduction in all four twitches during train-of-four stimulation No fade pattern observed Phase II Block (Presynaptic & Open Channel Mechanisms) Occurs with abnormally high doses or repeated administration : Phase I block progresses to a state resembling non-depolarizing blockade Characterized by: Presynaptic autoreceptor antagonism Succinylcholine has been shown to antagonize neuronal 32 nACh receptors with an IC50 that is ~10-times higher than its EC50 for stimulating the muscle-type (11) nACh receptors (Freeman, 1968
Frequency varies, but most users start with 1-2 sessions per week and adjust based on results
5.1.3 Modulating immune and inflammatory pathways Targeting key regulators such as NF-KB and Nrf2 can not only reduce proinflammatory cytokine production but also indirectly rebalance iron homeostasis
Supplement Smartly if Needed: As mentioned, supplements like N-acetylcysteine (NAC) can help supply the raw material for glutathione
Encourages cellular repair and immune resilience
Curcumin and turmeric products meet safety standards established by health authorities, such as the Food and Drug Administration (FDA), the Food and Agriculture Organisation of the United Nations (FAO), the World Health Organisation (WHO), and other relevant agencies that oversee food safety
