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However, Tomonaga et al

Reduced Bloating and Gas By helping to break down food more completely before it moves into the small intestine, enzymes may reduce the amount of gas produced during the digestive process

Active cancer or history of malignancy Pregnancy or breastfeeding Known peptide allergies Athletes subject to anti-doping testing (WADA prohibited) Raynauds disease or phenomenon Cold urticaria (hives from cold) Uncontrolled hypertension Peripheral vascular disease Open wounds (for local application) Pregnancy Cardiovascular conditions Diabetes (especially with neuropathy) Current infections Immunosuppression Blood clotting disorders Quality control issues represent perhaps the greatest practical risk with BPC-157

And the evidence so far shows that most users tolerate it well, even after years of use

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The compound has a favorable safety profile, with few reported side effects in the available literature