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In a clinical study, the treatment results lasted for 1 year after the first treatment session, for most of the patients,touch-up treatment can maintain the desired effect

The p53/p21 and p16/Rb (retinoblastoma) axes are the two central signaling pathways involved in senescence regulation

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doi:10.1042/AN20100033 Lukashev M, Zeng M, Goelz S, Lee D, Linker R, Drukach B, VanDam A (2007) Activation of Nrf2 and modulation of disease progression in EAE models by BG-12 (dimethyl fumarate) suggests a novel mechanism of action combining anti-inflammatory and neuroprotective modalities