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10.1186/s13023-022-02453-z Mashima Y, Kigasawa K, Wakakura M, Oguchi Y: Do idebenone and vitamin therapy shorten the time to achieve visual recovery in Leber hereditary optic neuropathy

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A polymorphism or variation in the sequence within an ER-response element located in the SELENOS promoter was found to result in reduced SELENOS promoter activity and gene expression (36)

Similarly, in SURMOUNT-1, 95% of tirzepatide-treated participants who had prediabetes at baseline reverted to normoglycemia, as compared with 62% of placebo-treated participants at Week 72 [16], with benefits shown to be sustained with additional 2-year follow-up [10]