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In combination with insulin (with or without metformin), sitagliptin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo (Table 14)

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Therefore, since we cant get enough cysteine from our diet and because increasing methionine is not a healthy option

This is the first Phase 3 GLP-1-class readout that specifically demonstrates symptomatic benefit in knee osteoarthritis beyond what would be expected from weight loss alone, and it opens the possibility, still to be confirmed in dedicated trials, that GLP-1 receptor signaling has direct anti-inflammatory or disease-modifying effects on joint tissue