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Currently, there is no direct evidence of basophils undergoing ferroptosis

Sulforaphane is an isothiocyanate compound found in raw cruciferous vegetables, such as broccoli and Brussel sprouts, and forms thiacyl adducts with Cys residues of Keap1, to release Nrf2 to translocate to the nucleus, resulting in the activation of antioxidant genes

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Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]