When to seek medical advice: Persistent vomiting or diarrhoea lasting more than 2448 hours contact GP or NHS 111 Symptoms suggestive of hypokalaemia (weakness, cramps, palpitations) contact GP Difficulty maintaining adequate fluid intake or reduced urine output contact GP or NHS 111 Chest pain, severe palpitations, or fainting call 999 or attend A&E Any concerns about medication side effects Patients should report suspected side effects via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)
Unlike FDA-approved medications, compounded medication does not undergo the same approval process as the FDA
Regarding the thyroid, oral semaglutide has a boxed warning regarding thyroid C-cell tumors, observed in rodent studies
The correct dose is set exclusively by clicking the pen
Most providers recommend starting tirzepatide the week after your last semaglutide injection at a dose that accounts for your current semaglutide level
The higher-dose semaglutide formulation for obesity (Wegovy, 2.4 mg weekly) can produce 10-15% weight loss, while diabetes doses typically yield more modest reductions
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