27 Point mutations in the DNA gyrase or topoisomerase IV genes confer fluoroquinolone resistance
10.1016/j.cortex.2015.08.022 Keywords VX Drug Class: Chemical Warfare Agent classified as a Nerve Agent Mechanism of Action & Effects: Routes of exposure: VX can be absorbed through the eyes or the skin of the victim As little as one drop of VX on the skin can be fatal (as compared to 1 to 10 mls of sarin or soman) The LD50 for humans is estimated to be ~10 mg Notes: Amber (honey brown) colored, tasteless & odorless, oily liquid with low volatility unless temperatures are high The V of VX signifies it very long persistence compared to sarin and soman VX decomposes at a rate of ~ 5% a month at 71 C VX-inhibited cholinesterase can be reactivated by 2-PAM for as long as 48 hours (Sidell & Groff : The reactivatibility of cholinesterase inhibited by VX and sarin in man
After stirring for another 1 h at 25 C, P3 (300 mg) was introduced to the reaction mixture
Mani BadalRBadalDBadalPKhareAShrivastavaJKumarV
Low levels of glutathione, especially in conditions of high oxidative stress, may lead to chronic disease and the loss of function associated with aging
While the body usually produces adequate glutathione, stress, poor diet, or a chronic health condition can reduce glutathione levels
