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Its effects on BDNF-related pathways and synaptic plasticity make it theoretically relevant to depression, though direct antidepressant research is limited

[103] Metformin [edit] Reduced serum levels of vitamin B 12 occur in up to 30% of people taking long-term anti-diabetic metformin

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Nat Cell Biol 8:13271336

doi:10.1007/s00213-019-05249-5 Aday JS, Mitzkovitz CM, Bloesch EK, Davoli CC, Davis AK