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Recent experimental studies revealed that folate may improve endothelial function 98 by an enhancement of binding affinity of BH 4 to NOS by a pteridine-binding domain serving as a locus through which the active form 5-methyl tetrahydrofolate facilitates the electron transfer by BH 4 from the NOS reductase domain to heme

In the landmark STEP 1 trial, participants lost an average of 14.9% of their body weight over 68 weeks

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