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That said, dosages up to 1,200 milligrams per day have been studied with no serious adverse effects reported. However, there isnt much long-term research with high doses of NMN, according to Jillian
Nicotinamide riboside-driven modulation of SIRT3/mtROS/JNK signaling pathways alleviates myocardial ischemia-reperfusion injury
J Biomed Res 2013;27:254-71
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Davis KE, Prasad C, Vijayagopal P, Juma S, Imrhan V
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