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The immune system shows sensitivity to both GSH deficiency and excess
However, this data comes from observational studies, not randomized controlled trials, so it should be interpreted cautiously
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Patients with AITD often suffer from Fe deficiency, as autoimmune gastritis, which reduces Fe absorption, and celiac disease, which causes Fe loss, are frequent comorbidities (105)
Defined as pain lasting three months or longer, it can manifest as localized discomfort from muscle strain or degenerative disc disease, or as radiating pain (lumbar radiculopathy) with numbness, tingling, or weakness, often due to nerve root compression
