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During oxidative stress and other stress, conditions increased levels of H 2 O 2 is associated with elevated production of antioxidant enzymes as a defense mechanism 31 that explains the upregulation of anti-oxidant pathways in both male and female livers treated with ibuprofen

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Therefore, restoration of CI function bypasses defects in lipogenic and nutrient-responsive transcription networks caused by circadian disruption in adipocytes

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