Optimizing the dosing, timing, and sequence of therapies is another hurdle, as improper administration could result in antagonistic interactions rather than synergistic benefits
Wajner M, Latini A, Wyse AT, Dutra-Filho CS
Daniel Drucker, a GLP-1 researcher
(2018) showed that compared to wild-type mice, SHANK3- and SHANK2-knockout mice had fewer glutamate receptors in the striatum and thalamus regions, while CNTN4 knock-out mice had fewer glutamate receptors in the cortex and hippocampus regions [60]
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Adherence to the treatment plan is the biggest predictor of long-term success