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Several mediators of apoptosis, pyroptosis, and necroptosis have been proposed to contribute to progressive neurodegeneration in experimental MS models [3,4,5,6,7,8], arguing for the involvement of multiple regulated cell death modalities (RCD) in this complex and heterogeneous pathology

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(AAOS Orthopaedic Sports Medicine) screened 544 peer-reviewed articles and identified 36 qualifying studies: 35 preclinical (rodent and dog models) and exactly 1 human trial

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