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Because the shot is fast and performed by trained staff, many patients find that the convenience outweighs any temporary discomfort

In Hashimoto's thyroiditis, the immunologic attack appears to be typically aggressive and destructive, rather than stimulatory, as in Graves' disease, and the difference is most likely due to the characteristics of the immune response

In the STEP 1 semaglutide trial (Wilding et al., NEJM , 2021) and the SURMOUNT-1 tirzepatide trial (Jastreboff et al., NEJM , 2022), nausea affected roughly 44% of semaglutide patients and about 24% of tirzepatide patients at the maximum dose

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