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In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)

These cell types are also impacted by G6PD and PPP activity with respect to ROS homeostasis and biosynthesis of effector molecules, and this can impact their downstream contribution to systemic inflammation

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"Homocysteine and Short-term Risk of Myocardial Infarction and Stroke in the Elderly"

10.1089/ars.2011.4281 Antioxid