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Similarly, the methylated derivative of resveratrol, pterostilbene, has been observed to upregulate Nrf2, HO-1, GSH, and GPX4 while reducing ACSL4 expression and iron content in H 2 O 2 -treated COV434 and KGN cells, suggesting a potential anti-ferroptotic effect ( In addition to the Nrf2/HO-1/GPX4 pathway, other pathways have been implicated

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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Chicca A., Marazzi J., Gertsch J

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Antioxidants 12 (2), 281