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Dosing and Administration: What to Expect Zepbound Dosing Schedule Zepbound is administered as a once-weekly subcutaneous injection: Weeks 1-4: 2.5 mg once weekly Weeks 5-8: 5 mg once weekly Weeks 9+: Increase by 2.5 mg every 4 weeks as tolerated Maintenance Dose: 5 mg, 10 mg, or 15 mg once weekly Most patients in clinical trials (89.3%) reached the maximum 15 mg dose, demonstrating good tolerability with gradual escalation

Novo Nordisk has studied a 50mg oral semaglutide dose in the OASIS 1 trial, where participants lost an average of 15.1% of body weight

However, this effect was less pronounced when assessed over 5 h (17 % following liraglutide 1.2 mg and 6 % [not significant] following 1.8 mg) [61]

Patients with personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should avoid semaglutide

The GLP-1 space really took off with semaglutide: first as Ozempic for type 2 diabetes in 2017, then as Wegovy for obesity in 2021