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Glucagon (GCG) is a 29 amino acid peptide secreted by pancreatic cells when blood glucose levels are low

PloS One 7, e30543 (2012)

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Some researchers suggest that acute spikes in plasma glucose trigger this stress (Papachristoforou et al., 2020), while others attribute it to glycemic variability (Rehman and Akash, 2017)