Ethics declarations Conflict of interest SC received lecture or consultancy fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly, MSD, Novo Nordisk
The association did not replicate in UK Biobank, although the expected power for replication in this cohort was low (Supplementary Table 11 and Supplementary Information)
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Although the permeability value of targeted nanocarriers were lower in case of BBB models on the inserts with 0.4 m pore size membranes, the significant difference between the non-targeted and targeted groups remained the same and the penetration of marker molecules across the BBB model on inserts with 3 m pore-size membranes or 0.4 m pore-size membranes were also similar
CoQ system Acetyl-CoA synthesizes steroids (squalene) and precursors of CoQ (farnesyl pyrophosphate) via the mevalonate (MVA) metabolic pathway [37, 44]
