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Dehydration from gastrointestinal side effects, as noted in FDA Medication Guides, may contribute substantially to headache development, especially during the initial treatment period when these effects are most pronounced

Steady state occurs after approximately 4-5 half-lives of consistent dosing

Reale M, Greig NH, Kamal MA

Unlike morning dosing, which gets built into the start-of-day routine, evening dosing competes with relaxation, family time, and simple exhaustion

If someone hears the first click and lifts the pen too early, they may not receive the full dose

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