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Both treatment groups exhibited a marked increase in Irs1 and Gck and a decline in Irs2 levels, owing to increased plasma insulin levels (Figure 1B)

Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, has shown impressive results in clinical trials with weight loss exceeding 24% in some studies

Thain A, Hart K, Ahmadi KR European journal of clinical nutrition 2025

Michael Calore: Maybe we can talk about some good news, because I know from reading your stories, that researchers are coming up with all kinds of data that's showing more positive effects of these drugs than just weight loss

In the above video Dr

Maghraby et al., 2025