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T2DM patients quickly lose muscle mass and muscle function, especially in the lower body, which is essential for mobility balance due to all these reasons (138)

10.1016/j.redox.2021.101979 107 Nascimento-CarvalhoB.da SilvaB

Apart from directly scavenging free radicals, glutathione also reactivates other antioxidants in the body

Headache and fatigue can occur, especially during dose increases

Although the mechanisms of acquired resistance in situ are still poorly understood, studies in vitro have shown that cells selected for resistance to one drug often exhibit cross-resistance to other seemingly unrelated agents, suggesting a somewhat generalised mechanism of resistance