For bakers and snack makers, the implications are brutal and potentially transformative
A practical approach: divide your daily electrolyte intake into 4-6 smaller portions spread across the day
doi: 10.1007/s40618-023-02050-2 97 NakamuraYMurakamiNIidaTAsanoSOzekiSNagaiT
Nonetheless, considering that the half-maximal effective concentration (EC 50 ) for Acetate, Propionate, and Butyrate is around 0.5 millimolar upon both GPR41 and GPR43 (292) and that the SCFA concentration in the human ileum and colon lumen is superior to 100 millimoles per kg (307309), it is likely that both receptors are constitutively active
[1] Licensed pharmacological options in the UK include orlistat (available at BMI 30 kg/m, or 28 kg/m with weight-related risk factors) and semaglutide (available within specialist weight management services as per NICE TA875, with adjusted BMI thresholds for some ethnic groups)
Need for more studies The other largest consistency seen across all articles is the call for more large-scale, high-quality studies to be done on this topic
