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Out-of-pocket costs are the strongest predictor of abandonment: High OOP costs drive non-adherence, especially in obesity, where coverage is limited and stigma persists

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A five-year clinical trial in which 619 hemodialysis patients who received 2.5 mg of folic acid, 1 mg of vitamin B12, and 50 mg of vitamin B6 daily had significantly lower plasma levels of homocysteine

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Also supports overall body composition, cognitive function, and metabolic health